Purdue researchers create device to identify risks for breast cancer

first_img News Purdue researchers create device to identify risks for breast cancer MaxiVision Eye Hospitals launches “Mucormycosis Early Detection Centre” Read Article Menopause to become the next game-changer in global femtech solutions industry by 2025 Share The missing informal workers in India’s vaccine story Related Postscenter_img The device is a small plastic case with several thin layers and an opening for a piece of paper where researchers can place a portion of tissueResearchers at Purdue University are creating a device that they hope will help identify risk factors that cause breast cancer.The device, known as risk-on-a-chip, is a small plastic case with several thin layers and an opening for a piece of paper where researchers can place a portion of tissue. This tiny environment produces risk factors for cancer and mimics what happens in a living organism.“We want to be able to understand how cancer starts so that we can prevent it,” said Sophie Lelièvre, Professor of Cancer Pharmacology, Purdue.The key to preventing cancer is understanding how it starts, but people generally don’t want to be prodded with potential carcinogens. Cancer is a disease of gene expression, and organisation of genes is specific to a particular species and organ, which means it wouldn’t be useful to perform this study on rats or mice. Thus, Lelièvre needs a model that will mimic the organ in question. She teamed up with Babak Ziaie, a professor of electrical and computer engineering at Purdue, to create the device.“Unlike conventional 2-D monolayer cell culture platforms, ours provides a 3-D cell culture environment with engineered gradient generators that promote the biological relevance of the environment to real tissue in the body,” said Rahim Rahimi, a graduate student in Ziaie’s lab.The risk-on-a-chip is based on an earlier cell culture device developed by Lelièvre and Ziaie to study cancer progression. To modify it for prevention, Ziaie plans to add nanosensors that measure two risk factors: oxidative stress and tissue stiffness.Oxidative stress is a chemical reaction that occurs as the result of diet, alcohol consumption, smoking or other stressors, and it alters the genome of the breast, aiding cancer development. The risk-on-a-chip will simulate oxidative stress by producing those molecules in a cell culture system that mimics the breast ducts where cancer starts.Tissue stiffness refers to the stiffness of breast tissue, which has been found to contribute to onset and progression of breast cancer. The research team will measure stiffness within a tunable matrix made of fibres, whose density is relative to stiffness.Breast cancer is particularly difficult to prevent because multiple risk factors work independently or in combination to promote disease onset. To account for this, the risk-on-a-chip will be tailorable to different groups of women at risk.“We need to see if there’s a difference in primary cells from black women or Asian women or white women, because that matters,” Lelièvre said. “The way our genome is organised depends on an individual’s ancestry and lifestyle; it’s very complex. That’s why cancer is so difficult to treat.”The research team believes the risk-on-a-chip could be used to study additional risks by adding more cell types and biosensors. They estimate that optimisation for each new condition will take between six months and a year.Lelièvre and Ziaie have received a joint grant from the Department of Defense (W81XWH-17-1-0250) to create and test the device with structures that mimic the mammary gland, which will provide more than $500,000 over the next two years.This project is part of the international breast cancer and nutrition collaboration. Indraprastha Apollo Hospitals releases first “Comprehensive Textbook of COVID-19” Phoenix Business Consulting invests in telehealth platform Healpha By salil sule on September 15, 2017 Heartfulness group of organisations launches ‘Healthcare by Heartfulness’ COVID care app WHO tri-regional policy dialogue seeks solutions to challenges facing international mobility of health professionalslast_img read more

Less Persons Killed in Crashes

first_imgRelatedLess Persons Killed in Crashes RelatedLess Persons Killed in Crashes RelatedLess Persons Killed in Crashes FacebookTwitterWhatsAppEmail The Road Safety Unit (RSU) is reporting a 27 per cent reduction in road fatalities since the start of 2010, when compared with the corresponding period for last year.Up to March 17, some 64 persons have been killed in motor vehicle crashes. This is 24 less than the 88 persons who died during the similar period last year. Twenty pedestrians were among the 64 persons killed, accounting for 44 per cent of the fatalities.Education and Information Officer at the RSU, Mr. Julian Thompson, said although he was pleased with the reductions in other categories, the high number of pedestrian deaths is unacceptable.“While we are grateful for the reduction in road fatalities, the Unit is still concerned about how pedestrians are using the roads. The RSU would like to urge pedestrians to utilise the areas of the roads designated for safe walking, such as pedestrian crossings, sidewalks and crosswalks,” he said.While urging all road users to practise safe usage of the roads, Mr. Thompson appealed to motorists to make a special effort to look out for pedestrians and pedal cyclists.“Pedestrians are the only group of road users without protective devices, therefore it is even more imperative to be vigilant and proactive about safety on the roads,” he stressed.The RSU is also reporting a 24 per cent reduction in fatal crashes. Since the start of the year, there have been 60 fatal crashes, compared to 79 for the corresponding period last year.center_img Less Persons Killed in Crashes LabourMarch 18, 2010 Advertisementslast_img read more

Home prices accelerate nationally as owners stay longer

first_imgHome prices are on the rise, and homeowners are opting to stay in their homes longer (Credit: iStock)The pace of rising home prices quickened in September and existing home sales ticked up 1.9 percent.Average home prices in cities across the nation rose 3.2 percent compared with the same period in the previous year, the Wall Street Journal reported. The year-over-year rise in August had been 3.1 percent.The gains mark a two-month departure from a long period of slowing growth in home prices.The gains were more moderate — just 2.1 percent — in the large urban areas tracked by the composite S&P CoreLogic Case-Shiller U.S. National Home Price Index.A separate report released last week by the Federal Housing Finance Agency echoed those findings, while the National Association of Realtors said existing home sales increased by 1.9 percent in October.Homeowners are choosing to stay in their homes longer, in part because of a dearth of affordable options and tax abatements for older homeowners, according to a Redfin study, the Washington Post reported. Owners in homes where walkable amenities are available are also less likely to move, and houses with higher walkability scores sell faster, the study found.The number of homes for sale in Washington, D.C., has fallen 38.1 percent since 2010, while the median sale price surged 36.7 percent to $410,000 from $299,900. Washington-area homeowners are also sticking around more — remaining in their homes for a median of 13 years, compared with just nine in 2010.[WSJ, WaPo] — Georgia Kromrei This content is for subscribers only.Subscribe Nowlast_img read more

I Have Learned

first_imgThrough this crisis I have learned many things. I have learned that the kindness of strangers can be a lifeline and that also there is no limit to selfish, greedy f***wits. I have learned to completely give up vanity and any beauty services and can live just fine with my roots showing and chipped nails. I have also learned that I care deeply about the sweet girl who cuts my hair and my single mom manicurist and am concerned how they will live without this essential income. I learned I have been putting on my make up in entirely the wrong way and am now an expert on “smoky eyes for those over 35.” I have learned you can work out for free online with German body builders. You can put a bit of dish liquid and water on the floor by the sink, hold onto the counter, and use the slippery floor as a treadmill. Toilet paper is actually a real and valuable currency. I have revisited Anselm’s ontological argument for the existence of god and have enough time to contemplate whether I agree or not.I have learned that many people out here do not fully understand the work of our amazing volunteer ambulance and fire fighters. The people on the front line of this epidemic are not paid. They only get a slight property tax relief for their duties. Unlike others who serve, they do not get salaries and pensions and health insurance. And they make this sacrifice when they need to care for their own families most.I have learned that those you might rely on are nowhere in sight and that a brief romance in Rome can lead to a deeply soulful connection that sends you strength from Beirut. A crisis pours gasoline on the flames of regret. Without distraction, time stops sprinting and slows to an unsteady gait. I have learned negativity is more negative and positivity is more positive although naivete is not rewarded. Not since the rotary phone have people made such an effort to call those they care about.A stiff upper lip is useful when drinking martinis, but if there was ever a time to ditch the sugar coating and be vulnerable, it is now. I have learned how loud the bird calls are and how often the ambulance siren is going by these days.I have learned that when there is one house on fire, everyone rushes to bring water to stop the flames, but when everyone’s house is on fire, you just try to get out alive.I have learned that it has taken a global crisis to shine the brightest possible light on the economic disparity of wealth in this country. Restaurant workers, staff for sporting, cultural, and conference events, the travel industry, those in the arts and theaters and music halls and museums, freelancers . . . the list goes on and on. I have learned that those who have not known the anxiety ridden, soul crushing, can’t sleep, shame inducing, ‘how did I get here as such a talented and hard-working person,’ ‘I used to bite my nails but now can’t put my fingers in my face’ experience of life may not truly understand.Yet those without financial worries cannot ignore the headlines of the economic impact on the majority of the population. And they do so at their own peril. Maybe when every woman has had their non-essential Botox injections cancelled, we will be able again to collectively raise an eyebrow at the inequity. Do not doubt our power.I have learned and I have learned and I have learned.But many have not.I have learned the importance of breath. Because in the end, that is the most important gift of [email protected] Sharelast_img read more

CAF U23 AFCON: Olympic Eagles To Begin Preparations Early – Coach Amapakabo

first_imgNigeria will start immediately planning towards retaining their U23 AFCON trophy and have “great expectations” about sealing qualification to the 2020 Olympics in Tokyo head coach of the Olympic Eagles Imama Amapakabo has said.The Olympic Eagles became the fourth team to qualify for the 2019 U23 AFCON behind hosts Egypt, Zambia and South Africa with a 5-0 trouncing of Sudan at the Stephen Keshi Stadium in Asaba on Wednesday.Trailing 1-0 from last Thursday’s first leg in Omdurman Nigeria took Sudan to the cleaners with Taiwo Awoniyi’s early goal setting the pace, before Ndifreke Effiong’s brace and a goal each from Sunday Faleye and Sunusi Ibrahim put an emphatic sheen to the scoreline.Replying to a question from Port Harcourt based journalistSammy Weijinya about the team’s readiness to pick an Olympic spot at the 2019U23 AFCON, Amapakabo said with qualification “done and dusted” the team wouldn’twait before the draws for the group stages before commencing preparations andhave “great expectations” about sealing an Olympics place.“This round of qualification is done and dusted; we arelooking forward to the group stage in Cairo,” he said. “We don’t know who ouropponents are but not until we get to know who they are [before we startpreparations].  I think we’re planningand I think the players are beginning to meet together and they are doing verywell, so Egypt here we come full of great expectations.”Amapakabo also suggested that his team had to deal with offthe field problems in the 1-0 loss to Sudan in Omdurman and said that the 5-0score line in the return fixture was a function of being able to spend moretime with the squad.“Sudan was an experience we would all want to forget interms of a whole lot, and as a coach, I said I don’t like to talk about off thefield incidents but then we got 1-0 we came back 5-0 a big score line becausewe’ve had the opportunity to work together to train together as a unit and as ateam.”The 2019 U23 AFCON is scheduled for 8-22 November in Egypt andthe top two teams will qualify to represent Africa at the 2020 Olympics inTokyo.Relatedlast_img read more